Nuclear and cytoplasmic determinants involved in the regulation of mammalian oocyte maturation and embryo development
Size is a fundamental biological feature that impacts physiology of the cell. This means not only the overal cell size but also the size of its organelles (subcellular structures). The basic aspect of size is its absolute value, having the upper and lower limits that are necessary for functional requirements. The mammalian oocyt or early-cleavage stage embryo represents, according to our opinion, an excellent experimental model systém. The present project aims to explore some fundamental questions of size scaling in mammalian oocytes and early embryos (nukleus, necleoli, chfomosomes, etc.). As some micromanipulation approaches are commonly used in understanding of nucleo-cytoplasmic interactions, size scalling mechanisms and realtedd consequences will enhance the efficiency of them.
|Period||2017 - 2019|
|Databse link (CZ)||GA17-08605S|
Nucleologenesis and nucleolotransfer in mammalian oocytes: A review
Mouse oocytes nucleoli rescue embryonic development of porcine enucleolated oocytes
The oocyte´s nucleolus precursor body: The globe for life
Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?
Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine
Dissecting the role of the germinal vesicle nuclear envelope and soluble
Assessing the effect of interspecies oocyte nucleolar material dosage on embryonic development
VÚŽV v.v.i. > Projects >