Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?

FULKOVÁ, Helena a LANGEROVÁ, Alena. Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?. Chromosome Research, 2019, 27, 129-140. ISSN 0967-3849.
Kateg. publikaceVědecké publikace impaktované
Interní odkaz19021.pdf
Abstrakt

Nucleoli are the site of ribosomal RNA production and subunit assembly. In contrast to active nucleoli in somatic cells, where three basic sub-compartments can be observed, mammalian oocytes and early embryos contain atypical nucleoli termed nucleolus-like bodies or nucleolus precursor bodies, respectively. Unlike their somatic counterparts, these structures are composed of dense homogenous fibrillar material and exhibit no polymerase activity. Irrespective of these unusual properties, they have been shown to be absolutely essential for embryonic development, as their microsurgical removal results in developmental arrest.

ProjektJaderné a cytoplazmatické determinanty zodpovědné za regulaci zrání oocytů a vývoj embrya
OdděleníBiologie reprodukce