Relationships between variable time, percentage of food restriction and liver histology: which alternative is the best for non-alcoholic fatty liver disease (NAFLD) prevention?
|Kateg. publikace||Vědecké publikace impaktované|
The objective of this study was to analyse the hepatic effects of food restriction in an experimental rabbit model. The study comprised 105 rabbits divided into 6 groups. The two control groups were fed ad libitum (ADL) during the entire experiment (CI and C2). The experimental groups were restricted between 42-49 days of age, where the rabbits received 50g (Rl) or 65g (R2) of food per rabbit per day. Others were restricted between 35-42 days of age, where the rabbits received 50g (R3) or 65g (R4) of food per rabbit per day. For liver analysis, 5 rabbits per group were slaughtered at the ages of 49, 56, 63, 70 days from the Rl, R2 groups and at 42, 49, 70 days from the R3, R4 groups. All animals from the CI and C2 groups developed steatosis with inflammation. Animals from the Rl and R2 groups developed steatosis without inflammation while in the R3 and R4 groups steatosis was not visible. In CI and C2 groups we observed mostly fatty deposit accumulations while in the Rl, R2, R3 and R4 groups, more PAS-positive material accumulations were visible. Liver steatosis correlated with inflammation development and interstitial tissue growth. These results can be used in clinical praxis as signs of NAFLD progression. Early food restriction had intense effects on liver morphology and it seems promising that similar approaches could be applied as preventive treatment for NAFLD development.
|Projekt||Řešení problematiky vybraných faktorů růstu ve vztahu ke kvalitě masa kuřat, krůt, králíků a nutrií|
|Oddělení||Fyziologie výživy a jakost produkce|
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