Provide methods of genomic evaluation for the most important diseases (primarily for clinical mastitis and foot and claw disorders) with genetic parameters, correlations and economic weights, to achieve genetic improvement for health traits of Holstein cattle. For sufficient amount of health data, create SW tools that allow compatibility, transmission, or sharing data from different sources. Motivation and support to that will be the creation of multi-level comparisons of sickness and treatment (benchmarking). Increase the efficiency of genotyping (sample type, validation of DNA isolation, industrialization of SNP analyzes) and extend it to new platforms associated with health and fitness; to acquire relationship matrix.Genome-wide association study for two selected congenital defects.