The amino-de-alkoxylation of the esterified polysaccharides with amines, hydroxylamine or hydrazine led to the formation of secondary amide, hydroxamic acid or hydrazide. Amides are highly stable organic compounds, which can be exploited for various other applications. The main advantage of this reaction is the easy isolation of the product from the reaction medium by precipitation or filtration; however, the purification of the product involves thorough washing by the organic solvent and acidified ethanol to remove excess reagent (free and in the form of amine salts) and degradation products. An interesting group of amidated polysaccharides are secondary amides with long alkyl chains. The newly prepared derivatives with long alkyl chains could be used as hydrophobic sorbent. New prepared derivatives of carboxymethylchitosan are also interesting derivatives that can be applied in different branches (medicine, pharmaceutical or food industry).