Antibiotic resistance represents a serious threat worldwide. Attention should be paid to multidrug resistant microorganism’s occurrence, which can be very exhausting for the breeder not only from the economic point of view. Therefore, alternative sources of antibacterials should be taken into account – there comes an application for various substances, including organic acids, clay minerals etc. Nowadays, the research in this field also focuses on the combinatory effect of such compounds, which can also find the perspective for use in the animal breeding.