Characterization of the new genetic variant in the caprine lipoprotein lipase gene
|Cathegory||Scientific publication in impacted journals|
Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyses the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins. By sequencing, we identified a four novel SNPs; one SNP involved a Gly→Arg AA substitution at position 23 of the signal peptide, and three SNPs in the intron I (KP261023) of the LPL locus. A protocol for rapid efficient simultaneous genotyping of LPL variants using the primer extension method (PEA) was described, and a total of 230 animals belonging to two goat breeds: White Shorthaired goat (n=177), and Brown Shorthaired goat (n=103) were genotyped. A total 15 genotype combinations were detected in tested goat populations.
Sztankóová Zuzana, Ing., Ph.D.
Mušková Michala, Ing
Vostrý Luboš, Doc. Ing., Ph.D.
Milerski Michal, Ing., Ph.D.
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