The paper focuses on the importance of adhering to the principles of good breeding practice to reduce the consumption of antimicrobials in farms. The basic principles of good breeding practice include first of all the quality of breeding management, ensuring an adequate level of young animals immunity, optimizing the breeding environment, nutrition and watering, and minimizing animal stress, exposure to pathogens, level of attended care to protect the health of farmed animals. The design and especially the strict adherence to the principles of good breeding practice plays a significant role in maintaining and gradually improving the health of animals in breeding, which also reduces the amount of antimicrobials and thus decreases the potential risk of antimicrobial resistance.