The study was aimed at evaluating the effect of the dietary inclusion of Camelina sativa (L.) Crantz cake (CS) on the growth performance and activities of pancreatic enzymes. Three experimental diets, differing in their main crude protein source, were formulated: the control diet (100 g/kg rapeseed cake), the CS5 diet (50 g/kg rapeseed cake and 50 g/kg camelina cake), and the CS10 diet (100 g/kg camelina cake). A total of 168 hybrid rabbits (line Hyplus PS 19 x Hyplus PS 40; of both sexes, 32 days old) were allocated to one of the three experimental groups (56 animals per group, 4 rabbits per cage) and were fed one of the three experimental diets for 42 days, at which time the animals were 74 days old. In addition, 30 hybrid rabbits (line Hyplus PS 19 x Hyplus PS 40; 32 days old, 830+-107 g live weight, both sexes) were used in a digestibility trial (10 rabbits per diet; data in process, not shown here). At the end of the digestibility trial, all rabbits (62 days old) were slaughtered, and samples of small intestinal content were collected for the analysis of pancreatic enzyme activities and the concentration of sialic acid. A lower average daily weight gain between 32 and 74 days of age (by 2.3 g; P=0.003), resulting in a lower final live weight at 74 days of age (by 122 g; P=0.007), was detected in rabbits fed the CS10 diet than in those fed the other diets. There was also a significantly lower average daily feed intake (by 5.5 g; P=0.031) and proteolytic activity in small intestine content (by 29.8 mg azocasein/g dry matter digesta/h; P=0.032) in rabbits fed with the CS10 diet than in rabbits fed the other diets. No mortality or morbidity occurred during the whole fattening period. In conclusion, adding 5% camelina cake to the diet had no detrimental effects on the rabbits‘ growth performance, health or the hydrolytic activities of pancreatic enzymes. The poorer growth performance in rabbits fed a diet with 10% CS cake necessitates determining the threshold of the dietary level of CS.