The aim of the study is to analyze potential risk factors involved in the spread of resistant bacteria in livestock farms, including preventive measures to maintain the good health of animals on the farm as an important prerequisite for reducing antimicrobial use. During processing, we based our work both on available domestic and foreign professional literature (Web of Science, PubMed) and, above all, on the practical experience of the authors in solving scientific research projects in the operating conditions of cattle, pigs, and poultry farms. The basis for disease prevention in livestock farming is the introduction and, above all, consistent adherence to preventive measures including the principles of good animal husbandry practice, prophylaxis, and biosecurity as an important prerequisite for maintaining good animal health and thus reducing the consumption of antimicrobial substances on farms with a subsequent reduction in the risk of the emergence and spread of antimicrobial resistance. Animals on farms with a high level of hygiene and nursing care with an optimally set herd/flock health management strategy, consistently adhering to the principles of good animal husbandry practice with an optimally set immunoprophylaxis and biosecurity program, will have higher resistance to disease agents. The above is a basic prerequisite for maintaining good animal health and for reducing the antimicrobial substances as an integral part of enabling the production of safe and biologically valuable raw materials and food of animal origin.