High doses of antibiotics and ZnO for growth promotion and diseases prevention in animals contributed to the antibiotic resistance. Antibiotics as growth promoters were banned by the European Parliament in 2003. In June 2022, the use of therapeutic doses of zinc oxide (ZnO) in compound feed for piglets will be banned. Post-weaning diarrhoea of piglets is caused by E. coli bacteria and is a big problem for many breeders. The solution of post weaning diarrhoea is not just about nutrition measures. The problem needs to be looked at comprehensively. The solution must also include hygienic measures to reduce the stress on the piglets as much as possible and to increase their resilience. The article is a review of possible nutritional intervention.