Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching

OOGA, Masatoshi, FULKOVÁ, Helena, HASHIMOTO, Satoshi, SUZUKI, Masatzaka G. a AOKI, Fugaku. Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching. Epigenetics, 2016, 11, 85-94. ISSN 1559-2294.
Kateg. publikaceVědecké publikace impaktované
Interní odkaz16027.pdf
Abstrakt

Zygotes are totipotent cells that have the ability to differentiate into all cell types. It is believed that this ability is lost gradually and differentiation occurs along with the progression of preimplantation development. We show that the loose chromatin structure is involved in the totipotency of one-cell stage embryos and that the change from loose to tight chromatin structure is associated with the loss of totipotency.

ProjektPřenosy jader somatických buněk u savců - reprogramace, remodelace nebo obojí?
OdděleníBiologie reprodukce