Chromatin in early mammalian embryos: achieving the pluripotent state
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Gametes of both sexes are highly specialized and terminally differentiated but within a very short time period after fertilization, both these genomes are converted into a totipotent embryo genome. Within further embryonic cleavages, this reprogramming continues but concomitantly certain differentiation processes occur. These changes are accompanied by DNA methylation and histone acetylation as well as with some others histone covalent modifications.
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