Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose
|Kateg. publikace||Příspěvky ve sbornících|
Hypercholesterolemia and obesity belong to the main risk factors of coronary heart disease, which is the leading cause of deaths worldwide. Several methods for the treatment of hypercholesterolemia exist, mainly fat restriction, the use of inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (statins), and sequestrans that bind bile acids in the small intestine and interrupt their enterohepatic circulation (Stedronsky, 1994). Increased conversion of cholesterol to bile acids in the liver compensates for the loss of bile acids in faeces, which results in reduction of cholesterolemia. An alternative to bile acid sequestrants are sorbents of sterols prepared by amidation of polysaccharides. In our recent study, the hypocholesterolemic effect of octadecylpectinamide was examined in rats fed diets containing cholesterol at 10 g for kg (Marounek et al., 2013). Amidated pectin supplied at 20, 40 and 60g for kg significantly decreased serum cholesterol from 3.32 (control) to 1.23 mikromol for ml in a dose-dependent manner. In a previous experiment, amidated pectin significantly increased the faecal excretion of natural sterols, and to a lesser extent also excretion of bile acids (Marounek et al., 2010). The aim of the present experiment was to compare the faecal output of sterols (both neutral and acidic), and fat in rats fed amidated celluloses prepared from oxidized monocarboxycellulose and carboxymethylcellulose. Female rats were chosen as the experimental animals, as female rats are more susceptible to changes in serum cholesterol by dietary means than male rats (Terpstra et al., 1982; Marounek et al., 2012).
|Projekt||Inhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy|
|Oddělení||Fyziologie výživy a jakost produkce|
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