β-glucan is substance that is very widely used in the pharmaceutical and food industries, medicine and other areas. This polysaccharide have immense significance in human metabolism. It is able to affect the levels of cholesterol and lipids. Chemical modification of this polysaccharide allows the support of these attributes. A main goal is to prepare a group of amide derivatives of carboxymethyl β-glucan to obtain a new group of polysaccharide derivatives and increase the benefits and attributes of β-glucan.