The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition
| Kateg. publikace | Vědecké publikace impaktované |
| Interní odkaz | 14030.pdf |
| Abstrakt | The oocyte (maternal) nucleolus is essential for early embryonic development and embryos originating from enucleolated oocytes arrest at the 2-cell stage. The reason for this is unclear. We demonstrated that whereas rRNA transcription activation and pre-rRNA processing are unaffected by the absence of NPB, this organelle is essential for the regulation of major and minor satellite sequences and consequently for normal development. |
| Projekt | Úloha a funkce jadérka v oogenezi a časném embryonálním vývoji |
| Oddělení | Biologie reprodukce |
| Pracovní skupina | Embryobiotechnologie |
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