Recently increasing interest in stem cells of mammalian ovary has been observed. Potential somatic stem cells for the follicular theca and ovarian surface epithelium have been demonstated. On the other hand, despite intensive research, difinitive evidence for stem cell characteristics of granulosa cells is still to be found. Elucidation of stem cell properties of follicular granulosa cells may have important implications both from scientific and clinical point of view. The aim of this work is to review the current knowledge about stem cell properties of cells constituting main somatic compartment of the mammalian ovary, namely granulosa cells.