Cholesterol and fat lowering with hydrophobic polysaccharide derivatives  

ČOPÍKOVÁ, J., TAUBNER, Tomáš, TŮMA, J., SYNYTSYA, A., DUŠKOVÁ, Dagmar a MAROUNEK, Milan. Cholesterol and fat lowering with hydrophobic polysaccharide derivatives  . Carbohydrate Polymers , 2015, 116, 207-214. ISSN 0144-5617.
Kateg. publikaceVědecké publikace impaktované
Interní odkaz15008.pdf

Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.

ProjektInhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy
OdděleníFyziologie výživy a jakost produkce