Despite the increased use of dry active Saccharomyces cerevisiae yeast supplementation in ruminant feeding, inconsistent results among studies hamper the prediction of its effects on animal performance. A meta-analysis has been conducted to quantify the magnitude of yeast supplementation effects on ruminal parameters, total tract nutrient digestibility, growth and feed conversion across different studies with sheep. Different methodologies and small numbers of studies necessitated the use of the classical effect size method, in which a unitless standardised effect size (Hedges’s g) was used to calculate differences obtained in outcomes between supplemented and non-supplemented sheep. Summary statistics across studies were calculated with fixed and random effects models, whereas subgroup-analysis and meta-regression were applied to identify possible interfering factors that could be responsible for between-study variability.