The health and longevity of the sows, as well as the vitality and nutritional independence of the piglets, are fundamental pillars of overall breeding efficiency. Parturition and the early postpartum period are critical periods for both sow and piglet. The objective of our study was to evaluate the drug application during these periods and its relationship with sow performance parameters (n = 1902). Basic farm data from 2016 to 2021 and a subsequent performance testing database (377108 records) were considered.