The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition
FULKOVÁ, H. & LANGEROVÁ, A. The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition. Development, 2014, roč. 141, s. 1694-1704. {INTLINK}
Year | 2014 |
Cathegory | Scientific publication in impacted journals |
Internal link | 14030.pdf |
Abstract | The oocyte (maternal) nucleolus is essential for early embryonic development and embryos originating from enucleolated oocytes arrest at the 2-cell stage. The reason for this is unclear. We demonstrated that whereas rRNA transcription activation and pre-rRNA processing are unaffected by the absence of NPB, this organelle is essential for the regulation of major and minor satellite sequences and consequently for normal development. |
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